Subcutaneous and transmucosal delivery of insulin.
نویسندگان
چکیده
منابع مشابه
Cellular evaluation of insulin transmucosal delivery.
P(MAA-g-EG) microparticles have been extensively investigated as carriers for oral delivery of proteins such as insulin. In this study, we investigated the effect of the molecular weight of the PEG tethered chains in the copolymer network and of the microparticle size on the transepithelial electrical resistance (TEER) and insulin epithelial permeability, using monolayers of human intestinal ep...
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Overcoming the barrier function of the skin already poses a great challenge to modern drug delivery systems, but no less important are safety and tolerability aspects. In the past, many common drug penetration enhancement strategies turned out to destroy the natural barrier function of the skin and cause irritations and other partially severe side-effects. Therefore, right from the beginning MI...
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OBJECTIVE Attempts to build an artificial pancreas by using subcutaneous insulin delivery from a portable pump guided by an subcutaneous glucose sensor have encountered delays and variability of insulin absorption. We tested closed-loop intraperitoneal insulin infusion from an implanted pump driven by an subcutaneous glucose sensor via a proportional-integral-derivative (PID) algorithm. RESEA...
متن کاملAdvances in oral transmucosal drug delivery.
The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities fo...
متن کاملTransmucosal delivery systems for calcitonin: a review.
The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents. The protection of these agents from biological fluids and physiological interactions is crucial for the treatment efficacy. One such agent is salmon calcitonin, a 32 amino-acid polypeptide hormone used in the tr...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2000
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.15.525